The full papers presented in the main track were carefully reviewed. They contain the latest advances on blockchain and artificial intelligence and on their application domains, exploring innovative ideas, guidelines, theories, models, technologies, and tools and identifying critical issues and challenges that researchers and practitioners must deal with in the future research. The authors would like to thank all the contributing authors, the members of the Program Committees, the sponsors, and the Organizing Committee of the University of Minho and the University of Salamanca for their hard and highly valuable work.